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BASIC PHARMACOKINETICS

Michael Makoid, Ph.D.; Phillip Vuchetich, Pharm.D.; Umesh Banakar, Ph.D.

Welcome to the first edition of Basic Pharmacokinetics on the web. An entire textbook for an introductory Pharmacokinetics course has been made especially for publication on the web in printed form using Adobe PDF format. In order to view the files, you must have an Acrobat Reader version 3.0 or later.
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Notice: The information contained herein may be used freely for personal or classroom use, but may not be sold or redistributed in any form without prior written consent from the authors.   Copying for classroom distribution must retain copyright notice and attributions.  Please download the most recent version. The works cited throughout the text and problem sets are copyrighted by their respective sources.

CURRENT NEWS: A Web-based classroom tool is under development.  It is intended to supplement the textbook and enhance the student's ability to learn new content as well as review previous material.  The differences in print versus online media may not permit all of the enhancements to benefit the book itself.  Thus, the PDF (print) version will continue to be available.

 

What's here:

How big:

Spread-
sheets

First Day of Class Information (103 KB)

Movies

Table of contents and publication information. (20 KB)
CHAPTER 1: Introduction (192 KB)
CHAPTER 2: Mathematics Review (534 KB)
CHAPTER 3: Pharmacological Response (189 KB)
CHAPTER 4: IV Bolus (431 KB)

CHAPTER 5: IV Infusion (246 KB) Exam 1
CHAPTER 6: Biopharmaceutical factors (4 KB)

PPT

CHAPTER 7: Oral Dosing (158 KB)

Basic
Workbook

CHAPTER 8: Bioavailability (426 KB)
CHAPTER 9: Clearance (330 KB)

Exam 2

CHAPTER 10: Dosage (119 KB)
CHAPTER 11: Multicompartment model* (400 KB)
CHAPTER 12: Protein Binding* (3 KB)
CHAPTER 13: Non-linear kinetics* (248 KB)
CHAPTER 14: Exams I (607 KB)
CHAPTER 15: Exams II (149 KB)
CHAPTER 16: Exams III* (17 KB)
Tolbutamide Exam and Answers
* MPS 443 Masters Level Basic Pharmacokinetics    

These pages will be updated periodically to include text updates and more problems. Comments and suggestions are welcome. It is my hope that this will become a viable source for anyone seeking this information.  If you have examples, problems, case studies that you would like to share, please email these to me and they will be included with proper attribution.  If you have a better way to explain the concepts described herein or concepts that you believe should be included, please contact me.   The information will be submitted for peer review and added under your authorship.   Mike Makoid

If you have questions on the content, talk with makoid@creighton.edu

If you have comments or suggestions on the format of the web pages or book, tell philv@creighton.edu